We loved staying at this property. It is by Pacific Beach / Mission Bay, so the vibe is a little different from the typical family-friendly neighborhood. However, since this house is set a little bit inside from the beach, it was always very quiet at night in the house. It has a sliver of a view of the ocean and the beach from the living room, but is otherwise surrounded by tightly packed houses. However, you can walk to either Mission Bay or Pacific Beach in less than a minute. We really appreciated having the garage to park our rental car since parking is hard to find in this neighborhood.
The one odd thing about this house is that the 2nd bedroom is an afterthought added to the back of the garage. To go from the main house to the second bedroom, you have to leave the house, go down the outside staircase, enter the garage and then enter the 2nd bedroom through it. This was not a problem for us because we have 2 teens and I think they actually liked that it was setup this way. The neighborhood felt very safe so we didn't have any concerns in that regard. However, if you have much younger children, you may want to reconsider.
The house was really clean and the agency which manages this rental were easy to communicate with and all the entry codes etc. were sent in a timely manner - so we had no issues getting into the house.
There is a nice large dining table and a decent sized kitchen for anyone who might want to cook a little while vacationing. On this trip, we chose to eat out at every meal and therefore didn't end up using the kitchen at all - so I can't comment on how well stocked it is. There are some really nice breakfast places within walking distance (Intazza - Good food), (Woody's - okay food, great views).
Finally, this place is a short drive away from a lot of touristy places - Balboa park, San Diego Zoo, San Diego Zoo Safari Park, Torrey Pines State park, and Beach towns like Del Mar, La Jolla, Cardiff, Encinitas. Nothing was more than 20ish minutes away by car.